Catalog No.: PC-49332Not For Human Use, Lab Use Only.
4-Sulfonic calix[8]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release.
4-Sulfonic calix[8]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release.
4-Sulfonic calix[8]arene shows IC50 of 191 nM and 214 nM for poly dA:dT-induced cell death and IL-1β release, respectively.
4-Sulfonic calix[8]arene is effective at blocking dsDNA-induced inflammasome activation in LPS-primed human blood monocyte-derived macrophages (hMDMs).
Physicochemical Properties
M.Wt
1507.5
Formula
C56H50O33S8
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4-Sulfocalix[8]arene hydrate
References
1. Jack P Green, et al. iScience. 2023 Apr 27;26(5):106758.
![4-Sulfocalix[8]arene hydrate](userfiles/product/PC-49332.gif)
