Chemical Structure : 4-Sulfocalix[8]arene hydrate
Catalog No.: PC-49332Not For Human Use, Lab Use Only.
4-Sulfonic calix[8]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release.
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4-Sulfonic calix[8]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release.
4-Sulfonic calix[8]arene shows IC50 of 191 nM and 214 nM for poly dA:dT-induced cell death and IL-1β release, respectively.
4-Sulfonic calix[8]arene is effective at blocking dsDNA-induced inflammasome activation in LPS-primed human blood monocyte-derived macrophages (hMDMs).
M.Wt | 1507.5 | |
Formula | C56H50O33S8 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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